Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 1381305Notes

Reaction equation

HRID 1381305 reaction equation
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

Product 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromideYield 79%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform was added and then the solution was separated. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe solution was separated
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-19a6f25ca8774068ae2d3f86dd036288
Source dataset
uspto-grants-1986_04
Patent number
US04585869

Reaction notes

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