Water → HCID 13491011, compound

HRID 1381326Notes

Reaction equation

HRID 1381326 reaction equation
[CH:1](=O)[C:2]([CH3:5])([CH3:4])[CH3:3].[CH3:7][NH:8][C:9](=[O:15])[C@H:10]([CH:12]([CH3:14])[CH3:13])[NH2:11].O>CCCCC>[CH3:7][NH:8][C:9](=[O:15])[C@H:10]([CH:12]([CH3:14])[CH3:13])[N:11]=[CH:1][C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 12417PivalaldehydeHCID 11423608N-Methyl-L-valinamide

Product 1

HCID 13491011HCID 13491011, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

There were added 95.7 ml (870 mmols) of pivalaldehyde to 112.0 grams (864 mmoles) of (S)-valine monomethylamide dissolved in 300 ml of n-pentane. The reaction mixture was boiled at a water separator until the formation of water was ended (4 hours). The solvent was removed under reduced pressure and there remained behind 130 grams (76% of theory) of (S)-N-(2',2'-dimethyl-propylidene)-valine monomethylamide, which could be further worked without purification. To ascertain the exact material data, a test of sample was purified by distillation.

Workup

  1. custom(4 hours)
  2. customThe solvent was removed under reduced pressure
  3. customcould be further worked without purification
  4. distillationa test of sample was purified by distillation

Sources & evidence

ORD record
ord-a1601df2703b4002ab9685e07e65ff28
Source dataset
uspto-grants-1986_04
Patent number
US04585892

Reaction notes

Loading…