反应详情

There were added 95.7 ml (870 mmols) of pivalaldehyde to 112.0 grams (864 mmoles) of (S)-valine monomethylamide dissolved in 300 ml of n-pentane. The reaction mixture was boiled at a water separator until the formation of water was ended (4 hours). The solvent was removed under reduced pressure and there remained behind 130 grams (76% of theory) of (S)-N-(2',2'-dimethyl-propylidene)-valine monomethylamide, which could be further worked without purification. To ascertain the exact material data, a test of sample was purified by distillation.

1. custom(4 hours)
2. customThe solvent was removed under reduced pressure
3. customcould be further worked without purification
4. distillationa test of sample was purified by distillation