Hydrazine hydrate (1:1) → 4-(3-Methoxypropyl)-3-thiosemicarbazide

Temperature

70 °C

A solution of methyl N-(3-methoxypropyl)-dithiocarbamate (100.2 g) in ethanol (300 ml) was added dropwise at 3° C. over 30 minutes to a solution of hydrazine hydrate (28 g) in ethanol (200 ml). The mixture was stirred for 4.5 hours at 70° C. The reaction mixture was concentrated and to the residue were added water and diethyl ether. The diethyl ether extract was dried over magnesium sulfate and evaporated in vacuo to give pinkish oil of 4-(3-methoxypropyl)thiosemicarbazide (89.9 g).

1. concentrationThe reaction mixture was concentrated and to the residue
2. additionwere added water and diethyl ether
3. extractionThe diethyl ether extract
4. dry with materialwas dried over magnesium sulfate
5. customevaporated in vacuo

ORD record

ord-b6579784a8904c7191214cbc7223af89

Source dataset

uspto-grants-1986_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04585872