Tetrahydrofuran → HCID 178460823, compound

HRID 1381355Notes

Reaction equation

HRID 1381355 reaction equation
[CH2:1]([S:4][C:5]1[N:9]=[C:8](Cl)[S:7][N:6]=1)[CH:2]=[CH2:3].NC(N)=[S:13].O1CCCC1>O>[CH2:1]([S:4][C:5]1[N:9]=[C:8]([SH:13])[S:7][N:6]=1)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 2723790ThioureaHCID 12151381HCID 12151381, compound

Product 1

HCID 178460823HCID 178460823, compoundYield 57.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-allylthio-5-chloro-1,2,4-thiadiazole (15.0 g), thiourea (5.95 g), tetrahydrofuran (45 ml) and water (15 ml) was gently boiled for 8.5 hours at 65° C. The reaction mixture was post-treated according to conventional manner to give powder of 3-allylthio-1,2,4-thiadiazole-5-thiol (8.5 g), mp. 107° to 108° C.

Workup

  1. additionThe reaction mixture was post-treated

Sources & evidence

ORD record
ord-f4d037ea194a49f3b84907119bf7c939
Source dataset
uspto-grants-1986_04
Patent number
US04585872

Reaction notes

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