Pyridine → 1H-Indole-2-carboxamide

HRID 1381490Notes

Reaction equation

HRID 1381490 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](Cl)=[O:11].[N:13]1C=CC=CC=1>C(Cl)Cl>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH2:13])=[O:11]

Participants

4

Reactant 2

HCID 1049PyridineHCID 118162081H-indole-2-carbonyl Chloride

Product 1

HCID 5948321H-Indole-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Indolyl carboxylic acid amides as starting materials may be produced by reacting an indolyl carboxylic acid chloride in absolute methylene chloride with an amine in the presence of pyridine at -10° to 0°.

Workup

  1. custommay be produced
  2. customat -10° to 0°

Sources & evidence

ORD record
ord-67316fcbfcd142438ae1f2e5231bef3d
Source dataset
uspto-grants-1989_02
Patent number
US04803199

Reaction notes

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