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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1381490Generated: November 2, 2026

Pyridine → 1H-Indole-2-carboxamide

https://huagongshe.com/reaction/1381490

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridineHCID 1049—
Reactant1H-indole-2-carbonyl ChlorideHCID 11816208—
SolventDichloromethaneHCID 6344—
Product1H-Indole-2-carboxamideHCID 594832—

Reaction Steps

Indolyl carboxylic acid amides as starting materials may be produced by reacting an indolyl carboxylic acid chloride in absolute methylene chloride with an amine in the presence of pyridine at -10° to 0°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04803199
Source datasetuspto-grants-1989_02
ORD IDord-67316fcbfcd142438ae1f2e5231bef3d
Source noteuspto-grants-1989_02