HCID 178492221, compound → HCID 14838481, compound

HRID 1381540Notes

Reaction equation

HRID 1381540 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:11]=2)=[CH:5][CH:4]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[CH:14]=[CH:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:11]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 178492221HCID 178492221, compound

Product 1

HCID 14838481HCID 14838481, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of the product of step (a) (13.3 g) in dichloromethane (250 ml) was added active manganese dioxide in portions until all traces of starting material had disappeared. The reaction mix was filtered, evaporated to a gum and purified by chromatography on silica, eluting with ether, to give the product, mp 68°-71°.

Workup

  1. additionThe reaction mix
  2. filtrationwas filtered
  3. customevaporated to a gum
  4. custompurified by chromatography on silica
  5. washeluting with ether
  6. customto give the product, mp 68°-71°

Sources & evidence

ORD record
ord-9676eb3bb7fd4448b220293bfb8a8515
Source dataset
uspto-grants-1989_02
Patent number
US04803216

Reaction notes

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