反应详情

To a solution of 8.9 g (0.041 mole) of 1-methyl-5-nitroindole-3-acetonitrile in 600 ml of THF was added 3 g of 10% Pd/C. The mixture was hydrogenated in a Parr apparatus at 50 psi for 6 hours. The resulting mixture was filtered through celite treated with charcoal and filtered again through celite. The solvent was removed in vacuo leaving 7.2 g of the tan solid. This material was used directly without purification for the next step.

1. filtrationThe resulting mixture was filtered through celite
2. additiontreated with charcoal
3. filtrationfiltered again through celite
4. customThe solvent was removed in vacuo