Hydrazine hydrate (1:1) → HCID 14032813, compound

HRID 1381569Notes

Reaction equation

HRID 1381569 reaction equation
O.[NH2:2][NH2:3].Br[C:5]1[N:9]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:12][C:11]=2[Cl:21])[N:8]=[CH:7][C:6]=1[S:22]([C:25]([F:28])([F:27])[F:26])(=[O:24])=[O:23]>O1CCOCC1>[Cl:21][C:11]1[CH:12]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:15]([Cl:16])[C:10]=1[N:9]1[C:5]([NH:2][NH2:3])=[C:6]([S:22]([C:25]([F:28])([F:27])[F:26])(=[O:24])=[O:23])[CH:7]=[N:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13748058HCID 13748058, compound

Product 1

HCID 14032813HCID 14032813, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

2.5 ml (0.065 mole) of hydrazine hydrate are added to 10 g (0.02 mole) of 5-bromo-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-trifluoromethylsulphonyl-pyrazole in 140 ml of dioxane at room temperature and the mixture is warmed at 60° C. with stirring for 4 hours. For work-up, the solvent is removed in vacuo and the oil remaining is purified by chromatography (silica gel, eluent: dichloromethane). 6.5 g (72% of theory) of 1-(2,6-dichloro-4-trifluoromethyl-phenyl)-5-hydrazino-4-trifluoromethylsulphonyl-pyrazole of melting point 154° C. are obtained.

Workup

  1. customFor work-up, the solvent is removed in vacuo
  2. customthe oil remaining is purified by chromatography (silica gel, eluent: dichloromethane)

Sources & evidence

ORD record
ord-c610d0d66bba4e91a292d7f92077baf4
Source dataset
uspto-grants-1989_02
Patent number
US04803215

Reaction notes

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