Hydrochloric Acid → HCID 14350447, compound

HRID 1381664Notes

Reaction equation

HRID 1381664 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=[O:15])[C:8](=[N:13]O)[C:9](=[O:12])[CH2:10][CH3:11])=[CH:3][CH:2]=1.Cl.CCOCC>C(O)(=O)C.[Zn]>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([OH:15])[CH:8]([NH2:13])[C:9](=[O:12])[CH2:10][CH3:11])=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178459333HCID 178459333, compound

Product 1

HCID 14350447HCID 14350447, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

In 20 ml acetic acid is dissolved 1.0 g of 1-(4-pyridyl)-1,3-diketo-2-oximinopentane with heat (50° C.). The solution is acidified with dry hydrogen chloride and 1.0 g of zinc dust is slowly added. The mixture is stirred for one hour and cooled. Dry ether is added to the mixture and the title compound precipitates from the solution as a crude solid. This may be used in subsequent steps without purification.

Workup

  1. additionis slowly added
  2. temperaturecooled
  3. customthe title compound precipitates from the solution as a crude solid
  4. customThis may be used in subsequent steps without purification

Sources & evidence

ORD record
ord-527e881f94b24ddf9d1ab732a9484a00
Source dataset
uspto-grants-1989_02
Patent number
US04803278

Reaction notes

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