Potassium cyanate → HCID 10376130, compound

HRID 1381666Notes

Reaction equation

HRID 1381666 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][C:6]([CH:9]([OH:16])[CH:10]([NH2:15])[C:11](=O)[CH2:12][CH3:13])=[CH:5][CH:4]=1.[O-:17][C:18]#[N:19].[K+]>O>[CH2:12]([C:11]1[NH:19][C:18](=[O:17])[NH:15][C:10]=1[CH:9]([OH:16])[C:6]1[CH:7]=[CH:8][N:3]=[CH:4][CH:5]=1)[CH3:13]

Participants

4

Reactant 2

HCID 11378442Potassium cyanateHCID 14350448HCID 14350448, compound

Product 1

HCID 10376130HCID 10376130, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

In 100 ml water is dissolved 29.0 g (0.11 mol) of 1-(4-pyridyl)-1-hydroxy-2-amino-3-ketopentane dihydrochloride and 17.9 g (0.22 mol) of potassium cyanate. The solution is warmed to 50° C. for 10 minutes and then allowed to stand at room temperature for 10 hours, cooled and the solid collected to give the title compound; m.p. 234°-36°.

Workup

  1. temperaturecooled
  2. customthe solid collected

Sources & evidence

ORD record
ord-f58775c30126458d840a18ae5394aa01
Source dataset
uspto-grants-1989_02
Patent number
US04803278

Reaction notes

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