Hydrochloric Acid → 6a(2)-Chloro-1-[6-(3-methyl-1,2,4-thiadiazol-5-yl)-3-pyridazinyl]spiro[piperidine-4,2a(2)(1a(2)H)-quinazolin]-4a(2)(3a(2)H)-one

HRID 138169Notes

Reaction equation

HRID 138169 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[Cl:19][c:20]1[n:21][n:22][c:23](-[c:26]2[n:27][c:28]([CH3:31])[n:29][s:30]2)[cH:24][cH:25]1.[Cl:2][c:3]1[cH:4][c:5]2[c:15]([cH:16][cH:17]1)[NH:14][C:8]1([NH:7][C:6]2=[O:18])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[ClH:1].[K+:36].[K+:37]>>[Cl:2][c:3]1[cH:4][c:5]2[c:15]([cH:16][cH:17]1)[NH:14][C:8]1([NH:7][C:6]2=[O:18])[CH2:9][CH2:10][N:11]([c:20]2[n:21][n:22][c:23](-[c:26]3[n:27][c:28]([CH3:31])[n:29][s:30]3)[cH:24][cH:25]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 258032626'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one

Product 1

HCID 685576916a(2)-Chloro-1-[6-(3-methyl-1,2,4-thiadiazol-5-yl)-3-pyridazinyl]spiro[piperidine-4,2a(2)(1a(2)H)-quinazolin]-4a(2)(3a(2)H)-one

Sources & evidence

ORD record
ord-ce957f2cb98641238e8d9f26dce7106b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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