Hydrochloric Acid → HCID 136332160, compound

HRID 1381764Notes

Reaction equation

HRID 1381764 reaction equation
[ClH:1].[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(OCC)C>CO>[ClH:1].[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 1363321599-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

Product 1

HCID 136332160HCID 136332160, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A twofold stoichiometric excess of 3% hydrogen chloride in methanol is added to a solution of 1.0 g. of 9-(1,3-di-n-octanoyloxy-2-propoxymethyl)guanine in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give 9-(1,3-di-n-octanoyloxy-2-propoxymethyl)guanine hydrochloride.

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-f37bf69e65e0417d9c2255e7b82d2096
Source dataset
uspto-grants-1989_02
Patent number
US04803271

Reaction notes

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