2-Amino-2-methyl-1,3-propanediol → 2-(((10-(1H-imidazol-1-yl)-9-anthracenyl)methyl)amino)-2-methyl-1,3-propanediol hydrochloride

HRID 1381787Notes

Reaction equation

HRID 1381787 reaction equation
CS(O)(=O)=O.[Cl:6]C1C2C(=CC=CC=2)C(CNC(O)C(C)CO)=C2C=1C=CC=C2.[N:29]1([C:34]2[C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[C:41]([CH:48]=O)=[C:40]3[C:35]=2[CH:36]=[CH:37][CH:38]=[CH:39]3)[CH:33]=[CH:32][N:31]=[CH:30]1.[NH2:50][C:51]([CH3:56])([CH2:54][OH:55])[CH2:52][OH:53]>>[ClH:6].[N:29]1([C:34]2[C:35]3[C:40](=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:41]([CH2:48][NH:50][C:51]([CH3:56])([CH2:54][OH:55])[CH2:52][OH:53])=[C:42]3[C:47]=2[CH:46]=[CH:45][CH:44]=[CH:43]3)[CH:33]=[CH:32][N:31]=[CH:30]1

Participants

4

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 1337540910-(1-H-Imidazol-1-yl)-9-anthracencarbaldehydeHCID 86741972((10-Chloro9-anthracenyl)methyl)amino-2-methyl-1,3-propanediol methanesulfonate

Product 1

HCID 133753302-(((10-(1H-imidazol-1-yl)-9-anthracenyl)methyl)amino)-2-methyl-1,3-propanediol hydrochloride

Procedure

Using the reductive amination procedure outlined in 2B, 10(1H-imidazol-1-yl)-9-anthracenecarbaldehyde (29A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-(((10-(1H-imidazol-1-yl)-9-anthracenyl)methyl)amino)-2-methyl-1,3-propanediol hydrochloride.11/10 H2O mp 212°-215° (dec), (EtOH/Et2O), (C, H, Cl, N).

Sources & evidence

ORD record
ord-21c4af6d10a24bffa7bf23b475b142fe
Source dataset
uspto-grants-1989_02
Patent number
US04803221

Reaction notes

Loading…