反应详情

温度

90 °C

To the product of Example 2 (120 mg) in acetonitrile (2 mL) was added acetoxyacetyl chloride (0.2 mL). The reaction was heated to 90° C. in a CEM microwave reactor for a total of 34 minutes. The reaction was diluted with EtOAc and was washed with saturated aqueous NaHCO3 solution. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-60% EtOAc in hexane affording the title compound. HPLC/MS: 572.1 (M+1), 574.1 (M+3); Rt=4.06 min.

1. washwas washed with saturated aqueous NaHCO3 solution
2. customThe concentrated residue was purified by flash chromatography on silica gel gradient
3. washeluted with 0-60% EtOAc in hexane affording the title compound