2-Amino-2-methyl-1,3-propanediol → HCID 21276289, compound

HRID 1381800Notes

Reaction equation

HRID 1381800 reaction equation
[C:1]([C:5]1[CH:18]=[CH:17][C:16]2[C:7](=[C:8]([CH:20]=O)[C:9]3[C:14]([C:15]=2[Cl:19])=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:22][C:23]([CH3:28])([CH2:26][OH:27])[CH2:24][OH:25]>>[ClH:19].[C:1]([C:5]1[CH:18]=[CH:17][C:16]2[C:7](=[C:8]([CH2:20][NH:22][C:23]([CH3:28])([CH2:26][OH:27])[CH2:24][OH:25])[C:9]3[C:14]([C:15]=2[Cl:19])=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 14370020HCID 14370020, compound

Product 1

HCID 21276289HCID 21276289, compound

Procedure

Using the reductive amination procedure described in 1, 2-tert-butyl-10-chloro-9-anthracenecarbaldehyde (41B) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-(((2-tert-butyl-10-chloro-9-anthracenyl)methyl)amino)-2-methyl-1,3-propanediol hydrochloride.1/4H2O mp 249°-250° (dec), (EtoH/Et2O), (C, H, Cl, N).

Sources & evidence

ORD record
ord-7c996a52485543498c7b8c6d0c2d3153
Source dataset
uspto-grants-1989_02
Patent number
US04803221

Reaction notes

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