2-Isopropyl-2-nitro-1,3-propanediol acetate → 2-Amino-2-isopropyl-1,3-propanediol acetate

HRID 1381811Notes

Reaction equation

HRID 1381811 reaction equation
C(O)(=O)C.N[C@@](C)([C@H](O)C)CO.[C:13]([O:16][CH2:17][C:18]([CH:24]([CH3:26])[CH3:25])([N+:21]([O-])=O)[CH2:19][OH:20])(=[O:15])[CH3:14]>>[C:13]([O:16][CH2:17][C:18]([NH2:21])([CH:24]([CH3:25])[CH3:26])[CH2:19][OH:20])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 538480152-Isopropyl-2-nitro-1,3-propanediol acetateHCID 86741969(+-)(2R*,3R*)-2-amino-2-methyl-1,3-butanediol acetate

Product 1

HCID 143912482-Amino-2-isopropyl-1,3-propanediol acetate

Procedure

Using the procedure in 5E, 2-isopropyl-2-nitro-1,3-propanediol acetate mp 155°-155.5°. H. S. Broadbent et al., J. Heterocyclic Chem., 13, 337 (1975) report the synthesis of this compound as the free base (mp 70°-72°)).

Sources & evidence

ORD record
ord-de273b80cc5141ef8c305e8934962dfb
Source dataset
uspto-grants-1989_02
Patent number
US04803222

Reaction notes

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