2-Amino-2-methyl-1-propanol → 2-((3-Fluoranthenylmethyl)-amino)-2-methyl-1-propanol hydrochloride

HRID 1381815Notes

Reaction equation

HRID 1381815 reaction equation
[ClH:1].[CH:2]1[C:16]2=[C:17]3[C:9]([C:10]4[C:15]2=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]([CH2:18][NH:19][C:20]([CH3:25])([CH2:23]O)[CH2:21][OH:22])[CH:3]=1.C1C2=C3C(C4C2=CC=CC=4)=CC=CC3=C(C=O)C=1.CC(N)(C)CO>CO.CCOCC>[ClH:1].[CH:2]1[C:16]2=[C:17]3[C:9]([C:10]4[C:15]2=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]([CH2:18][NH:19][C:20]([CH3:25])([CH3:23])[CH2:21][OH:22])[CH:3]=1

Participants

5

Reactant 3

HCID 118072-Amino-2-methyl-1-propanolHCID 1811133-FluoranthenecarboxaldehydeHCID 3024572773U82 Hydrochloride

Product 1

HCID 134899382-((3-Fluoranthenylmethyl)-amino)-2-methyl-1-propanol hydrochloride

Reagents, catalysts & solvents 1

HCID 21864698Diethyl ether methanolSolvent

Procedure

Using the reductive amination procedure outlined in 1D, 3-fluoranthenecarbaldehyde (1A) and 2-methyl-2-aminopropanol (Aldrich) gave 2-((3-fluoranthenylmethyl)-amino)-2-methyl-1-propanol hydrochloride, mp 288°-290° (dec), (CH3OH/Et2O), (C, H, Cl, N).

Sources & evidence

ORD record
ord-2a246a7fa07845dcaa21e6e3143c7f7a
Source dataset
uspto-grants-1989_02
Patent number
US04803222

Reaction notes

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