Formaldehyde → HCID 14402875, compound

HRID 1381821Notes

Reaction equation

HRID 1381821 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][C:10](=[O:13])[NH:9][C:8]=2[CH:14]=1)([O-:3])=[O:2].[CH2:15]=[O:16]>O>[OH:16][CH2:15][N:9]1[C:8]2[CH:14]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=2[O:12][CH2:11][C:10]1=[O:13]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 27636836-Nitro-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 14402875HCID 14402875, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred mixture composed of 6-nitro-2H-1,4-benzoxazin-3(4H)-one (5.82 g), 37% formaldehyde aqueous solution (28.5 ml) and water (5.4 ml) is refluxed for 2 hours, and cooled. The resultant solid is collected by filtration, washed with water, ethanol, ether and n-hexane successively, and dried to obtain 4-hydroxymethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (5.19 g).

Workup

  1. temperatureis refluxed for 2 hours
  2. temperaturecooled
  3. filtrationThe resultant solid is collected by filtration
  4. washwashed with water, ethanol, ether and n-hexane successively
  5. customdried

Sources & evidence

ORD record
ord-aa3598be69ea4cb394988fc01f5463b8
Source dataset
uspto-grants-1989_02
Patent number
US04804394

Reaction notes

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