Formaldehyde → HCID 14402875, compound

Participants

Reaction Steps

A stirred mixture composed of 6-nitro-2H-1,4-benzoxazin-3(4H)-one (5.82 g), 37% formaldehyde aqueous solution (28.5 ml) and water (5.4 ml) is refluxed for 2 hours, and cooled. The resultant solid is collected by filtration, washed with water, ethanol, ether and n-hexane successively, and dried to obtain 4-hydroxymethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (5.19 g).

Provenance & Evidence