Hydrochloric Acid → (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride

HRID 1381861Notes

Reaction equation

HRID 1381861 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[CH2:6][CH2:5]1)(=O)C.[ClH:20]>>[ClH:20].[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 18759874(2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochlorideYield 83%

Procedure

A mixture of 48 parts of 1-acetyl-4-(2,4-difluorobenzoyl)-piperidine and 180 parts of a hydrochloric acid solution 6N was stirred and refluxed for 5 hours. The reaction mixture was evaporated and the residue was stirred in 2-propanol. The product was filtered off and dried, yielding 39 parts (83%) of (2,4-difluorophenyl)(4-piperidinyl)methanone hydrochloride (intermediate 2).

Workup

  1. temperaturerefluxed for 5 hours
  2. customThe reaction mixture was evaporated
  3. stirringthe residue was stirred in 2-propanol
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-50661ae016c041d9b334a4f93df23494
Source dataset
uspto-grants-1989_02
Patent number
US04804663

Reaction notes

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