反应详情

A mixture of 48 parts of 1-acetyl-4-(2,4-difluorobenzoyl)-piperidine and 180 parts of a hydrochloric acid solution 6N was stirred and refluxed for 5 hours. The reaction mixture was evaporated and the residue was stirred in 2-propanol. The product was filtered off and dried, yielding 39 parts (83%) of (2,4-difluorophenyl)(4-piperidinyl)methanone hydrochloride (intermediate 2).

1. temperaturerefluxed for 5 hours
2. customThe reaction mixture was evaporated
3. stirringthe residue was stirred in 2-propanol
4. filtrationThe product was filtered off
5. customdried