Hydroxyamine hydrochloride → (2,4-Difluorophenyl)(piperidin-4-yl)methanone

HRID 1381862Notes

Reaction equation

HRID 1381862 reaction equation
Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[C:10]([CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:11].Cl.NO>C(O)C>[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[C:10]([CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 18759874(2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride

Product 1

HCID 13076388(2,4-Difluorophenyl)(piperidin-4-yl)methanoneYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 12 parts of (2,4-difluorophenyl)(4-piperidinyl)methanone hydrochloride, 12 parts of hydroxylamine hydrochloride and 120 parts of ethanol was stirred at room temperature and 10.5 parts of N,N-diethylenethanamine were added. The whole was stirred and refluxed for 3 hours. After cooling, the precipitated product was filtered off and dried, yielding 11 parts (100%) of (2,4-difluorophenyl)(4-piperidinyl)methanone, oxime (intermediate 3).

Workup

  1. stirringThe whole was stirred
  2. temperaturerefluxed for 3 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitated product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-4333703cc0864ecb972934c38ec05c48
Source dataset
uspto-grants-1989_02
Patent number
US04804663

Reaction notes

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