2-(Trifluoromethyl)benzoyl chloride → HCID 21275295, compound

HRID 1381875Notes

Reaction equation

HRID 1381875 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[F:16][C:17]([F:28])([F:27])[C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][N:13]([C:20](=[O:21])[C:19]3[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=3[C:17]([F:16])([F:27])[F:28])[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

Product 1

HCID 21275295HCID 21275295, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5 g of 1-[2-(4-chlorophenyl)-ethyl]piperazine are dissolved in 75 ml of dichloromethane, and a solution of 4.65 g of 2-trifluoromethylbenzoyl chloride is added dropwise within a period of 10 minutes. The whole is heated under reflux for 5 minutes, allowed to stand at room temperature for 1 hour, is concentrated to dryness by evaporation, extracted with warm acetone and precipitated with hexane. 1-[2-(4-chlorophenyl)-ethyl]-4-(2-trifluoromethylbenzoyl)-piperazine hydrochloride having a melting point of 212°-214° is obtained.

Workup

  1. temperatureThe whole is heated
  2. temperatureunder reflux for 5 minutes
  3. concentrationis concentrated to dryness by evaporation
  4. extractionextracted with warm acetone
  5. customprecipitated with hexane

Sources & evidence

ORD record
ord-3476a8e72de94cdb8e1937f9bcc1bb3e
Source dataset
uspto-grants-1989_02
Patent number
US04804661

Reaction notes

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