2-(Trifluoromethyl)benzoyl chloride → HCID 21275295, compound

Participants

Reaction Steps

5 g of 1-[2-(4-chlorophenyl)-ethyl]piperazine are dissolved in 75 ml of dichloromethane, and a solution of 4.65 g of 2-trifluoromethylbenzoyl chloride is added dropwise within a period of 10 minutes. The whole is heated under reflux for 5 minutes, allowed to stand at room temperature for 1 hour, is concentrated to dryness by evaporation, extracted with warm acetone and precipitated with hexane. 1-[2-(4-chlorophenyl)-ethyl]-4-(2-trifluoromethylbenzoyl)-piperazine hydrochloride having a melting point of 212°-214° is obtained.

Provenance & Evidence