2,6-Dimethylbenzoyl chloride → HCID 21275319, compound

HRID 1381878Notes

Reaction equation

HRID 1381878 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([Cl:6])=[O:5].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1>C(Cl)Cl>[ClH:6].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:4](=[O:5])[C:3]3[C:2]([CH3:1])=[CH:10][CH:9]=[CH:8][C:7]=3[CH3:11])[CH2:25][CH2:26]2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 890962,6-Dimethylbenzoyl chlorideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

Product 1

HCID 21275319HCID 21275319, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 11.1 g of 2,6-dimethylbenzoyl chloride in 50 ml of methylene chloride is added dropwise, over a period of 10 minutes, to a solution, stirred at room temperature, of 13.5 g of 1-[2-(4-chlorophenyl)-ethyl]-piperazine in 100 ml of methylene chloride. The reaction mixture is stirred overnight at room temperature. The suspension is filtered with suction and washed with ice-cold methylene chloride and finally with ether, dried and characterised in the form of the hydrochloride which has a melting point of 259°-261°. 1-[2-(4-chlorophenyl)-ethyl]-4-(2,6-dimethylbenzoyl)-piperazine hydrochloride is thus obtained.

Workup

  1. filtrationThe suspension is filtered with suction
  2. washwashed with ice-cold methylene chloride and finally with ether
  3. customdried

Sources & evidence

ORD record
ord-dff33bbf24e54fb0904107f1adca6bd0
Source dataset
uspto-grants-1989_02
Patent number
US04804661

Reaction notes

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