2,6-Dimethylbenzoyl chloride → HCID 21275319, compound

Participants

Reaction Steps

A solution of 11.1 g of 2,6-dimethylbenzoyl chloride in 50 ml of methylene chloride is added dropwise, over a period of 10 minutes, to a solution, stirred at room temperature, of 13.5 g of 1-[2-(4-chlorophenyl)-ethyl]-piperazine in 100 ml of methylene chloride. The reaction mixture is stirred overnight at room temperature. The suspension is filtered with suction and washed with ice-cold methylene chloride and finally with ether, dried and characterised in the form of the hydrochloride which has a melting point of 259°-261°. 1-[2-(4-chlorophenyl)-ethyl]-4-(2,6-dimethylbenzoyl)-piperazine hydrochloride is thus obtained.

Provenance & Evidence