2-(Trifluoromethyl)benzoyl chloride → HCID 21275295, compound

HRID 1381883Notes

Reaction equation

HRID 1381883 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([Cl:7])=[O:6].[Cl:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:17][CH:16]=1>C(Cl)Cl>[ClH:7].[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][N:24]([C:5](=[O:6])[C:4]3[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=3[C:2]([F:13])([F:12])[F:1])[CH2:23][CH2:22]2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

Product 1

HCID 21275295HCID 21275295, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4.65 g of 2-trifluoromethylbenzoyl chloride in 50 ml of methylene chloride is added dropwise, over a period of 10 minutes, to a solution, stirred at room temperature, of 5 g of 1-(4-chlorophenethyl)-piperazine in 75 ml of methylene chloride. The reaction mixture is heated under reflux for 5 minutes, allowed to stand at room temperature for 1 hour and then concentrated by evaporation. The residue is made into a slurry with hot acetone and, after the addition of hexane, the whole is filtered. 1-(4-chlorophenethyl)-4-(2-trifluoromethylbenzoyl)piperazine hydrochloride having a melting point of 212°-214° is obtained.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureunder reflux for 5 minutes
  3. concentrationconcentrated by evaporation
  4. additionafter the addition of hexane
  5. filtrationthe whole is filtered

Sources & evidence

ORD record
ord-241e9b8820bb4bfbb337f691252e3298
Source dataset
uspto-grants-1989_02
Patent number
US04804661

Reaction notes

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