2-(Trifluoromethyl)benzoyl chloride → HCID 21275295, compound

Participants

Reaction Steps

A solution of 4.65 g of 2-trifluoromethylbenzoyl chloride in 50 ml of methylene chloride is added dropwise, over a period of 10 minutes, to a solution, stirred at room temperature, of 5 g of 1-(4-chlorophenethyl)-piperazine in 75 ml of methylene chloride. The reaction mixture is heated under reflux for 5 minutes, allowed to stand at room temperature for 1 hour and then concentrated by evaporation. The residue is made into a slurry with hot acetone and, after the addition of hexane, the whole is filtered. 1-(4-chlorophenethyl)-4-(2-trifluoromethylbenzoyl)piperazine hydrochloride having a melting point of 212°-214° is obtained.

Provenance & Evidence