Methylamine → HCID 14369789, compound

HRID 1381893Notes

Reaction equation

HRID 1381893 reaction equation
[CH3:1][NH2:2].[CH3:3][C:4]1[N:5]=[C:6]([C:15]([O:17]C)=O)[S:7][C:8]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1>C(O)C>[CH3:1][NH:2][C:15]([C:6]1[S:7][C:8]([C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)=[C:4]([CH3:3])[N:5]=1)=[O:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 14369785HCID 14369785, compound

Product 1

HCID 14369789HCID 14369789, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl amine (0.5 ml) was added to a stirred solution of methyl 4-methyl-5-(4-pyridinyl)-thiazole-2-carboxylate (250 mg) in absolute ethanol (10 ml) at room temperature, and the mixture was stirred at room temperature for overnight. The mixture was evaporated to dryness and the residue was recrystallized from iso-propanol to give N,4-dimethyl-5-(4-pyridinyl)-thiazole-2-carboxamide (200 mg, yield 80.0%) as pale yellow needles.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue was recrystallized from iso-propanol

Sources & evidence

ORD record
ord-bc92dde5e4354d728c4fe8fcb5f3982c
Source dataset
uspto-grants-1989_02
Patent number
US04804668

Reaction notes

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