N,N-Dimethylethylenediamine → HCID 14369792, compound

HRID 1381895Notes

Reaction equation

HRID 1381895 reaction equation
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH2:5].[CH3:7][C:8]1[N:9]=[C:10]([C:19](OC)=[O:20])[S:11][C:12]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1>O>[CH3:7][C:8]1[N:9]=[C:10]([C:19]([NH:5][CH2:4][CH2:3][N:2]([CH3:6])[CH3:1])=[O:20])[S:11][C:12]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 14369785HCID 14369785, compound

Product 1

HCID 14369792HCID 14369792, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N-Dimethylethylenediamine (1.4 ml) was added to a suspension of methyl 4-methyl-5-(4-pyridinyl)-thiazole-2-carboxylate (200 mg) in water (2.8 ml) at room temperature, and the mixture was stirred at room temperature for overnight. The mixture was evaporated to dryness and the residue was chromatographed on an activated alumina column and eluted with chloroform to give 4-methyl-N-(2-dimethylaminoethyl)-5-(4-pyridinyl)-thiazole-2-carboxamide as yellow oil.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue was chromatographed on an activated alumina column
  3. washeluted with chloroform

Sources & evidence

ORD record
ord-262bb35c65954509a1ab9924d9a55c9b
Source dataset
uspto-grants-1989_02
Patent number
US04804668

Reaction notes

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