反应详情

m-Chloroperbenzoic acid (28.8 g) was added dropwise to a stirred solution of 5-methyl-2H-1,4-thiazin-3(4H)-one (15 g) in methanol (300 ml) under ice-cooling and the mixture was stirred at room temperature for 1 day. After the mixture was evaporated to dryness, the residue was extracted with ethyl acetate, washed with saturated sodium bicarbonate aqueous solution and dried over anhydrous magnesium sulfate. The solvent was evaporated to dryness to give 2-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one (11.3 g, yield 61%) as pale yellow powder.

1. temperaturecooling
2. customAfter the mixture was evaporated to dryness
3. extractionthe residue was extracted with ethyl acetate
4. washwashed with saturated sodium bicarbonate aqueous solution
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was evaporated to dryness