反应详情

To the product of EXAMPLE 33 (77 mg) in CH2Cl2 (2 mL) was added Cs2CO3 (43.7 mg) in methanol (1 mL). The reaction stirred at room temperature for 2.5 hours before diluting with EtOAc. The reaction was washed with brine and 10% aqueous NaHSO4 solution. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-65% EtOAc in hexane affording the title compound. HPLC/MS: 530.1 (M+1), 532.1 (M+3); Rt=3.85 min.

1. washThe reaction was washed with brine and 10% aqueous NaHSO4 solution
2. customThe concentrated residue was purified by flash chromatography on silica gel gradient
3. washeluted with 0-65% EtOAc in hexane affording the title compound