Potassium Carbonate → HCID 21275375, compound

HRID 1381908Notes

Reaction equation

HRID 1381908 reaction equation
Cl[CH:2]([CH3:15])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5].[CH2:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:16]([N:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH:2]([CH3:15])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 480381-Heptanamine, N-ethyl-HCID 21275370HCID 21275370, compound

Product 1

HCID 21275375HCID 21275375, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reflux 5.0 g (21 mmol) of 3-chloro-N-[2-phenylethyl]butanamide, 3.0 gm (21 mmol) N-ethylheptanamine and 3.0 g (21 mmol) of potassium carbonate in 100 mL of methanol. Follow the progress of the reaction by thin layer chromatography on silica gel. At the completion of the reaction remove the solvent in vacuo and add 100 mL of H2O. Extract the aqueous mixture with 3×100 mL of methylene chloride. Dry the organic extracts over anhydrous sodium sulfate. Remove the drying agent and evaporate the solvent to obtain the title compound.

Workup

  1. customthe progress of the reaction by thin layer chromatography on silica gel
  2. customAt the completion of the reaction remove the solvent in vacuo
  3. additionadd 100 mL of H2O
  4. extractionExtract the aqueous mixture with 3×100 mL of methylene chloride
  5. dry with materialDry the organic extracts over anhydrous sodium sulfate
  6. customRemove the drying agent
  7. customevaporate the solvent

Sources & evidence

ORD record
ord-ae8fb9c43b2f47dc80c4e19cadd9e580
Source dataset
uspto-grants-1989_02
Patent number
US04804662

Reaction notes

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