HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(1H-imidazol-1-yl)benzoate → N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(1H-imidazol-1-yl)benzoate | HCID 2766374 | — |
| Reactant | N1,N1-Dibenzylethane-1,2-diamine | HCID 6394114 | — |
| Product | N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate | HCID 67833593 | — |
Reaction Steps
Heat 4.23 g (21.0 mmol) of 4-(1H-imidazol-1-yl)benzoic acid methyl ester and 5.00 g (21.0 mmol) of N,N-dibenzylethylenediamine in 10 mL of xylenes at reflux for about 48 hr. Cool the solution to room temperature. Filter to obtain crystals of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04804662 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-c768e08e13ee4479b9ccd4c63185e2fa |
| Source note | uspto-grants-1989_02 |