Hydrochloric Acid → HCID 21275434, compound

HRID 1381947Notes

Reaction equation

HRID 1381947 reaction equation
C(OC([N:11]1[CH2:25][CH2:24][C:14]2([C:18](=[O:19])[N:17]([N:20]([CH3:22])[CH3:21])[C:16](=[O:23])[CH2:15]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[ClH:26]>>[ClH:26].[CH3:21][N:20]([CH3:22])[N:17]1[C:16](=[O:23])[CH2:15][C:14]2([CH2:24][CH2:25][NH:11][CH2:12][CH2:13]2)[C:18]1=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21275436HCID 21275436, compound

Product 1

HCID 21275434HCID 21275434, compound

Conditions

Temperature
100 °C

Procedure

To the 8-benzyloxycarbonyl-2-dimethylamino-2,8-diazaspiro[4,5]decane-1,3-dione (0.4 g) which was obtained in Example 18 was added 6N hydrochloric acid (20 ml), and was followed by heating at 100° C. for 3 hours. The solvent was then evaporated; the resulting residual solid was recrystallized from ethanol-ethyl acetate to obtain 0.3 g of a colorless crystal having a melting point of from 257° to 260° C.

Workup

  1. customThe solvent was then evaporated
  2. customthe resulting residual solid was recrystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-412a9c4074654fcc855e1cd11d7a5a9b
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

Loading…