Hydrochloric Acid → HCID 21275442, compound

HRID 1381952Notes

Reaction equation

HRID 1381952 reaction equation
[ClH:1].Cl.C([N:10]1[CH2:29][CH2:28][C:13]2([C:17](=[O:18])[N:16]([O:19]CC3C=CC=CC=3)[C:15](=[O:27])[CH2:14]2)[CH2:12][CH2:11]1)C1C=CC=CC=1>[Pd].CO>[ClH:1].[OH:19][N:16]1[C:15](=[O:27])[CH2:14][C:13]2([CH2:12][CH2:11][NH:10][CH2:29][CH2:28]2)[C:17]1=[O:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21275455HCID 21275455, compound

Product 1

HCID 21275442HCID 21275442, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a mixture solvent consisting of methanol (100 ml) and 1N hydrochloric acid (50 ml) was dissolved 8-benzyl-2-benzyloxy-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride (16.0 g). The solution was subjected to catalytic reduction at 40° C. for 12 hours under atmospheric pressure, using palladium as the catalyst. After the reaction, the catalyst was removed, and the solvent was evaporated off under reduced pressure. The residual solid was recrystallized from ethanol to obtain 8.9 g of a colorless solid, m.p. 250° to 277° C.

Workup

  1. customAfter the reaction
  2. customthe catalyst was removed
  3. customthe solvent was evaporated off under reduced pressure
  4. customThe residual solid was recrystallized from ethanol

Sources & evidence

ORD record
ord-440df8b502784df39e5cfedddaa105a7
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

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