Methanol → HCID 14371876, compound

HRID 1381958Notes

Reaction equation

HRID 1381958 reaction equation
[CH3:1][OH:2].C(OC([N:13]1[CH2:27][CH2:26][C:16]2([C:20](=[O:21])[N:19](CC#N)[C:18](=[O:25])[CH2:17]2)[CH2:15][CH2:14]1)=O)C1C=CC=CC=1.C[N:29]([CH3:32])C=O>[Pd]>[C:32]([CH2:1][O:2][N:19]1[C:18](=[O:25])[CH2:17][C:16]2([CH2:15][CH2:14][NH:13][CH2:27][CH2:26]2)[C:20]1=[O:21])#[N:29]

Participants

5

Reactant 3

HCID 887MethanolHCID 6228DimethylformamideHCID 21275427HCID 21275427, compound

Product 1

HCID 14371876HCID 14371876, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a mixture solvent consisting of methanol (10 ml) and dimethylformamide (10 ml) was dissolved 8-benzyloxycarbonyl-2-cyanomethyl-2,8-diazaspiro[4,5]decane-1,3-dione (0.6 g). The solution was subjected to catalytic hydrogenation for 5 hours at room temperature and under atmospheric pressure, using palladium as the catalyst. The catalyst was removed, and the solvent was evaporated off, then, the residual solid was recrystallized from ethanol to obtain 0.38 g of a coloress solid, m.p. 273° to 278° C.

Workup

  1. customThe catalyst was removed
  2. customthe solvent was evaporated off
  3. customthe residual solid was recrystallized from ethanol
  4. customto obtain 0.38 g of a coloress solid, m.p. 273° to 278° C.

Sources & evidence

ORD record
ord-6e90fe2fa12443d2abc5270d122dea56
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

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