2-Bromoethanol → HCID 14371877, compound

HRID 1381959Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:20][CH2:19][C:11]2([C:15](=[O:16])[N:14]([OH:17])[C:13](=[O:18])[CH2:12]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:22][CH2:23][OH:24]>>[C:1]([O:5][C:6]([N:8]1[CH2:20][CH2:19][C:11]2([C:15](=[O:16])[N:14]([O:17][CH2:22][CH2:23][OH:24])[C:13](=[O:18])[CH2:12]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 108982-Bromoethanol

HCID 14371872HCID 14371872, compound

Product 1

HCID 14371877HCID 14371877, compound

Procedure

Employing 8-tert-butyloxycarbonyl-2-hydroxy-2,8-diazaspiro[4,5]decane-1,3-dione (0.56 g) and 2-bromoethanol (210 μl), reaction was conducted in the same manner as in Example 40 to obtain 0.40 g of a coloress solid, m.p. 97° to 98° C.

Workup

customto obtain 0.40 g of a coloress solid, m.p. 97° to 98° C.

Sources & evidence

ORD record: ord-b7126bfba7394b379053b83cfddaf96b
Source dataset: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04804665

Reaction notes

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