Methyl bromoacetate → HCID 21275437, compound

HRID 1381961Notes

Reaction equation

HRID 1381961 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:20][CH2:19][C:11]2([C:15](=[O:16])[N:14]([OH:17])[C:13](=[O:18])[CH2:12]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:21][O:22][C:23](=[O:26])[CH2:24]Br>>[C:1]([O:5][C:6]([N:8]1[CH2:20][CH2:19][C:11]2([C:15](=[O:16])[N:14]([O:17][CH2:24][C:23]([O:22][CH3:21])=[O:26])[C:13](=[O:18])[CH2:12]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 14371872HCID 14371872, compound

Product 1

HCID 21275437HCID 21275437, compound

Procedure

Employing 8-tert-butyloxycarbonyl-2-hydroxy-2,8-diazaspiro[4,5]decane-1,3-dione (0.56 g) and methylbromoacetate (190 μl), reaction was conducted in the same manner as in Example 40 to obtain an oily compound. This was separated by column chromatography (eluent; dichloromethane) to obtain 0.67 g of a coloress oily compound.

Workup

  1. customto obtain an oily compound
  2. customThis was separated by column chromatography (eluent; dichloromethane)

Sources & evidence

ORD record
ord-9e260b3c0b2f495a9b9ffe993952a4e4
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

Loading…