Hydrochloric Acid → HCID 13657445, compound

HRID 1381993Notes

Reaction equation

HRID 1381993 reaction equation
[Cl:1][C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]([F:14])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>C(O)C.O>[Cl:1][C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]([F:14])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13986835HCID 13986835, compound

Product 1

HCID 13657445HCID 13657445, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

68 g of this tetrafluoroborate are thermally decomposed in o-dichlorobenzene. After work-up, 15 g of methyl 2,4-dichloro-5-fluoro-3-methylbenzoate of boiling point 139°-40° C. (16 mbar) are obtained. 12.8 g of this ester are boiled for 11/2 hours with 4 g of NaOH in 100 ml of ethanol/water. After cooling, the mixture is acidified with HCl and filtered under suction. 12 g of the title compound are obtained. Melting point 167°-69° C.

Workup

  1. custom2 hours
  2. temperatureAfter cooling
  3. filtrationfiltered under suction

Sources & evidence

ORD record
ord-bfd312a5738c41ed9c371bacde2e4144
Source dataset
uspto-grants-1989_02
Patent number
US04804760

Reaction notes

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