Ammonia → HCID 178472080, compound

HRID 1382001Notes

Reaction equation

HRID 1382001 reaction equation
[Cl:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[C:18]([Cl:23])[C:17]([F:24])=[CH:16][C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[NH3:25]>C(O)C>[NH2:25][CH:12]=[C:6]([C:4](=[O:5])[C:3]1[CH:16]=[C:17]([F:24])[C:18]([Cl:23])=[C:19]([N+:20]([O-:22])=[O:21])[C:2]=1[Cl:1])[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 53944414Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

Product 1

HCID 178472080HCID 178472080, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

38 g of the product from Example 1 are intitially introduced into 40 ml of ethanol. A mixture of 8 ml of concentrated NH3 solution in 25 ml of ethanol is added dropwise with ice cooling. The mixture is stirred for 2 hours at room temperature and the phases are then separated. The organic phase is washed with water and dried. 38.3 g of the title compound remain on concentration.

Workup

  1. additionis added dropwise with ice cooling
  2. customthe phases are then separated
  3. washThe organic phase is washed with water
  4. customdried
  5. concentration38.3 g of the title compound remain on concentration

Sources & evidence

ORD record
ord-a0a1df0fb3fa461bad80ef8c291d42ba
Source dataset
uspto-grants-1989_02
Patent number
US04804760

Reaction notes

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