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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1382046Generated: October 25, 2026

Sucrose → L-Aspartyl-D-alanine N-(2,2,4,4-tetramethyltetrahydrothiophene-3-yl)amide

https://huagongshe.com/reaction/1382046

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSucroseHCID 5988—
Reactant(3S)-3-amino-4-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-4-oxobutanoic acidHCID 11571987—
Reactant3-Amino-2,2,4,4-tetramethyltetrahydrothiopheneHCID 13733567—
ProductL-Aspartyl-D-alanine N-(2,2,4,4-tetramethyltetrahydrothiophene-3-yl)amideHCID 13247912—

Reaction Steps

When levorotatory 3-amino-2,2,4,4-tetramethyltetrahydrothiophene, resolved by standard methods, was employed in the above procedure in place of the racemic amine the resulting L-aspartyl-D-alanine amide was found to be 800 times as sweet as sucrose.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04804782
Source datasetuspto-grants-1989_02
ORD IDord-fa20bc9e27154a16a777a6cea6761026
Source noteuspto-grants-1989_02