Hydrochloric Acid → 2-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acid

HRID 1382100ノート

反応式

HRID 1382100 の反応式
[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([O:14]CC)=[O:13])[N:10]=1)([CH3:4])(=[O:3])=[O:2].[OH-].[Na+].Cl>O>[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([OH:14])=[O:13])[N:10]=1)([CH3:4])(=[O:2])=[O:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19978726Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate

生成物 1

HCID 199787632-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acid収率 81.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate (13.9 g.) was added with stirring at ambient temperature to a solution of sodium hydroxide (5.0 g.) in water (150 ml.). The mixture was stirred for 1 hour at ambient temperature, adjusted to pH 7 with conc. hydrochloric acid and washed with ethyl acetate. The aqueous layer was adjusted to pH 0.5 with conc. hydrochloric acid to precipitate yellow crystals. The crystals were collected by filtration, washed with water and dried to give 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylic acid (10.16 g.).

後処理

  1. washwashed with ethyl acetate
  2. customto precipitate yellow crystals
  3. filtrationThe crystals were collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-1f2a6ba9131d4220b50a3d87fb74b9fa
出典データセット
uspto-grants-1989_02
特許番号
US04804752

反応ノート

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