Potassium Hydroxide → HCID 14392500, compound

HRID 1382144Notes

Reaction equation

HRID 1382144 reaction equation
[Cl:1][C:2]1[C:14]([N:15]2[C:19](=[O:20])[N:18]([CH:21]([F:23])[F:22])[C:17]([CH3:24])=[N:16]2)=[CH:13][C:5]([O:6][CH:7]([CH3:12])[C:8]([O:10]C)=[O:9])=[C:4]([CH3:25])[CH:3]=1.[OH-].[K+]>C(O)C.O>[Cl:1][C:2]1[C:14]([N:15]2[C:19](=[O:20])[N:18]([CH:21]([F:22])[F:23])[C:17]([CH3:24])=[N:16]2)=[CH:13][C:5]([O:6][CH:7]([CH3:12])[C:8]([OH:10])=[O:9])=[C:4]([CH3:25])[CH:3]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 14392489HCID 14392489, compound

Product 1

HCID 14392500HCID 14392500, compoundYield 84.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

In a manner similar to Example 2, Step H, the reaction of 3.3 g (0.0088 mole) of methyl 2-[4-chloro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)-2-methylphenoxy]propionate with 1.5 g (0.27 mole) of potassium hydroxide in 50 mL of ethanol and 15 mL of water produced 2.7 g of 2-[4-chloro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)-2-methylphenoxy]propionic acid as a solid (mp 56°-60° C.), Compound A3.

Sources & evidence

ORD record
ord-45bbbde6503545a0b28694b00d0c1d03
Source dataset
uspto-grants-1989_02
Patent number
US04806145

Reaction notes

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