Potassium Hydroxide → HCID 14392500, compound

Participants

Reaction Steps

In a manner similar to Example 2, Step H, the reaction of 3.3 g (0.0088 mole) of methyl 2-[4-chloro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)-2-methylphenoxy]propionate with 1.5 g (0.27 mole) of potassium hydroxide in 50 mL of ethanol and 15 mL of water produced 2.7 g of 2-[4-chloro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)-2-methylphenoxy]propionic acid as a solid (mp 56°-60° C.), Compound A3.

Provenance & Evidence