Hydrazine hydrate (1:1) → HCID 14581292, compound

HRID 1382190Notes

Reaction equation

HRID 1382190 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)=[CH:13][CH:12]=1.O.[NH2:25][NH2:26]>CCO>[N:17]1([C:14]2[CH:15]=[CH:16][C:11]([C:10]3[C:5]4[C:4](=[CH:9][CH:8]=[CH:7][CH:6]=4)[C:3](=[O:2])[NH:26][N:25]=3)=[CH:12][CH:13]=2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14581296HCID 14581296, compound

Product 1

HCID 14581292HCID 14581292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of methyl-2-[4-(1H-imidazol-1-yl)benzoyl]benzoate (1.3 g, 4.25 mmol) in 15 mL of EtOH is treated with hydrazine monohydrate (0.26 g, 5.20 mmol) and heated to reflux for 1 day. The white solid which precipitates is filtered and recrystallized from EtOH to give 4[4-(1H-imidazol-1-yl)phenyl]-1-oxo-1,2-dihydrophthalazine. M.P. 309.5°-311° C.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 day
  3. customThe white solid which precipitates
  4. filtrationis filtered
  5. customrecrystallized from EtOH

Sources & evidence

ORD record
ord-58ca327db3874e6b87593d9daf0ee661
Source dataset
uspto-grants-1989_02
Patent number
US04806535

Reaction notes

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