HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 13961103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | HCID 19834214 | HCID 19834214 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 13961103 | HCID 13961103 | 77.8% |
Reaction Steps
0.75 g (1.9 mmol) of N-[2-[1-(2-carboxyethyl)-1H-indol-3-yl]ethyl]-(4-fluorophenyl)sulphonamide are reduced with triethylsilane analogously to Example 1. 0.58 g of a viscous oily product is thus obtained (Rf =0.18, CH2Cl2 :ethyl acetate=100:2). After conversion of the product into its hydrochloride (analogously to Example 1), 0.62 g (76% of theory) of a solid residue is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806551 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-c279b0ba9d494bf694bf839e96a385ad |
| Source note | uspto-grants-1989_02 |