HCID 178496227, compound → HCID 11776709, compound

HRID 1382276Notes

Reaction equation

HRID 1382276 reaction equation
[CH3:1][O:2][CH2:3][C:4]([C:6](=[CH:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20])[C:7]([O:9]C)=O)=[O:5]>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:1][O:2][CH2:3][C:4]([C:6]1[C:7](=[O:9])[C:18]2[C:13](=[C:14]([O:19][CH3:20])[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)=[O:5]

Participants

3

Reactant 1

HCID 178496227HCID 178496227, compound

Product 1

HCID 11776709HCID 11776709, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Methyl 2-methoxyacetyl-3-(2-methoxyphenylamino)acrylate (55 g, 0.2 mol) was added in portions to boiling diphenyl ether (500 ml) and the mixture was heated under reflux for 45 minutes. The mixture was allowed to cool and diluted with petroleum ether to afford 3-methoxyacetyl-8-methoxy-4(1H)-quinolone (40 g, 82.5%) as light brown crystals.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 minutes
  3. temperatureto cool

Sources & evidence

ORD record
ord-38c2f93e7efb4bf28e603e26d7620bd3
Source dataset
uspto-grants-1989_02
Patent number
US04806549

Reaction notes

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