反应详情

Ethyl 2-butyryl-3-(2-methylphenylamino)acrylate (66 g, 0.24 mol) was added in portions to boiling diphenyl ether (500 ml), then heated at reflux for 1.5 hours. After partial cooling, the mixture was poured into high boiling petroleum ether. Filtration and washing with petroleum ether gave 3-butyryl-8-methyl-4(1H)-quinolone (54 g) as a pale solid, which was used without further purification.

1. temperatureheated
2. temperatureat reflux for 1.5 hours
3. additionAfter partial cooling, the mixture was poured
4. filtrationFiltration
5. washwashing with petroleum ether