反应详情

3-Butyryl-8-methyl-4(1H)-quinolone (20 g) and phosphoryl chloride (80 ml) were heated under reflux for 45 minutes. Excess phosphoryl chloride was evaporated in vacuo, the residue poured onto ice and neutralised with sodium hydrogen carbonate. Extraction with dichloromethane, drying and evaporation gave 3-butyryl-4-chloro-8-methylquinoline (20 g) as a brown oil, which solidified at -15° C. but melted below room temperature. This was used without further purification.

1. temperatureunder reflux for 45 minutes
2. customExcess phosphoryl chloride was evaporated in vacuo
3. additionthe residue poured onto ice and neutralised with sodium hydrogen carbonate
4. extractionExtraction with dichloromethane
5. customdrying
6. customevaporation